University: West Bengal University
Course: B.sc Microbiology
Subject : Computational Biology & Bio-Informatics
Year of Question Paper : 2013
CS/B.Sc.(H)/BT/Gen/Micro-Bio/Mol-Bio/SEM-4/CBB-402/2013
2013
COMPUTATIONAL BIOLOGY & BIOINFORMATICS
Time Allotted : 3 Hours Full Marks : 70
The figures in the margin indicate full marks.
Candidates are required to give their answers in their own words
as far as practicable.
GROUP – A
( Multiple Choice Type Questions )
1. Choose the correct alternatives for any ten of the following : [Marks 10 × 1 = 10]
i) Which of these is not a protein sequence database ?
a) PIR b) GenBank
c) PDB d) Swiss-Prot.
ii) BCA stands for
a) Bacteria Artifice Chromosome
b) Bacterial Artifice Chromosome
c) Bacterial Artificial Chromosome
d) Bacterial Artificial Chromatid.
iii) Which step is omitted in whole genome sequencing ?
a) Random shqedding of genome
b) Making phage library
c) Computational analysis
d) None of these.
iv) Which of the following is not primary nucleotide
sequence database ?
a) DDBJ b) OWL
c) GEN BANK d) EMBL.
v) URL for NCBI is
a) www.ncbi.nlm.nih.gov b) www.ncbi.nih.nlm.gov
c) www.ncbi.gov d) www.ncbi.nlm.gov.
vi) Clastal W
a) multiple sequence alignment tool
b) protein secondary structure predicting tool
c) data retrieving tool
d) nucleic acid sequence analysis tool.
vii) Which is data retiring tool ?
a) KEGG b) EMBL
c) ENTERZ d) PHD.
viii) BLAST & FASTA are used for
a) global similarity
b) end free space alignment
c) local similarity
d) gap penalty.
ix) Information of all known nucleotide & protein sequel are
available on
a) NCBI gene bank b) DDBJ
c) EMBL d) all of these.
x) What is the primary goals of databases ?
a) Minimizing data redundancy
b) Achieving data independence
c) Both (a) and (b)
d) None of these.
xi) Phylogenetic relationship can be shown by
a) Dendogram b) Data search tool
c) Data retrieving d) Gene bank.
xii) Proteomics research can be categorized as
a) structural proteomics & functional proteomics
b) structural functional & comparative functional
c) functional & comparative proteomics
d) none of these.
GROUP – B
( Short Answer Type Questions )
Answer any three of the following. [Marks 3 × 5 = 15]
2. Define WWW, HTTP, HTML, URL.
3. What is substitution matrix ? Write down the difference
between PAM & BLOSUM matrix. [Marks 2 + 3]
4. What is sequence alignment ? Write about E value & Z score. [Marks 2 + 3]
5. Write down the difference between FASTA & BLAST. [Marks 2 + 3]
6. Write about data retrieval tool. What is sequin & bankit ? [Marks 2 + 3]
GROUP – C
( Long Answer Type Questions )
Answer any three of the following. [Marks 3 × 15 = 45]
7. a) What is Secondary Database ? Name two Secondary
Databases.
b) What is the difference between Accession Number and
Gi Number ?
c) What are the basis of database searching in
bioinformatics ?
d) What do you mean by BankIT ? [Marks 1 + 2 + 4 + 5 + 3]
8. a) Compare the features between Primary, Secondary and
Tertiary database.
b) What is PFAM and BLOCKS ?
c) Write down the differences between Flat File and
Hierarchical files.
d) Why Biological Database are important ? [Marks 5 + 3 + 4 + 3]
9. What is Dynamic Programming ? What are the general steps
of it ? Name two database searching tools. Fill the matrix for
DP and align the following sequences :
GAATTCAGTTA (sequence#1) (Upto Matrix fill step only)
GGATCGA (sequence#2) [Marks 2 + 1 + 2 + 7 + 3]
10. What is substitution matrix ? In "PAM 250" the 250 stands
for what ? Write down the difference of PAM 250 and
BIOSSM 62 matrix. What is humming and levenstein
distance ? Write down one name of two small molecule
database. What is Pubmed ? What is the name of the
database where you get the inheritable disease of human ?
What is word size ? Comment on sensitivity and selectivity ?
[Marks 1 + 1 + 3 + 4 + 1 + 1 + 1 + 1 + 2]
11. State the difference between homology and similarity ? Write
down 6 emerging fields in bioinformatics. You have given a
sequence of African elephant and Indian elephant how would
you draw the phylogenetic relation between them ? What
would you expect the result. What is relative mutability ? [Marks 3 + 3 + 4 + 2 + 3]
=============..
Course: B.sc Microbiology
Subject : Computational Biology & Bio-Informatics
Year of Question Paper : 2013
CS/B.Sc.(H)/BT/Gen/Micro-Bio/Mol-Bio/SEM-4/CBB-402/2013
2013
COMPUTATIONAL BIOLOGY & BIOINFORMATICS
Time Allotted : 3 Hours Full Marks : 70
The figures in the margin indicate full marks.
Candidates are required to give their answers in their own words
as far as practicable.
GROUP – A
( Multiple Choice Type Questions )
1. Choose the correct alternatives for any ten of the following : [Marks 10 × 1 = 10]
i) Which of these is not a protein sequence database ?
a) PIR b) GenBank
c) PDB d) Swiss-Prot.
ii) BCA stands for
a) Bacteria Artifice Chromosome
b) Bacterial Artifice Chromosome
c) Bacterial Artificial Chromosome
d) Bacterial Artificial Chromatid.
iii) Which step is omitted in whole genome sequencing ?
a) Random shqedding of genome
b) Making phage library
c) Computational analysis
d) None of these.
iv) Which of the following is not primary nucleotide
sequence database ?
a) DDBJ b) OWL
c) GEN BANK d) EMBL.
v) URL for NCBI is
a) www.ncbi.nlm.nih.gov b) www.ncbi.nih.nlm.gov
c) www.ncbi.gov d) www.ncbi.nlm.gov.
vi) Clastal W
a) multiple sequence alignment tool
b) protein secondary structure predicting tool
c) data retrieving tool
d) nucleic acid sequence analysis tool.
vii) Which is data retiring tool ?
a) KEGG b) EMBL
c) ENTERZ d) PHD.
viii) BLAST & FASTA are used for
a) global similarity
b) end free space alignment
c) local similarity
d) gap penalty.
ix) Information of all known nucleotide & protein sequel are
available on
a) NCBI gene bank b) DDBJ
c) EMBL d) all of these.
x) What is the primary goals of databases ?
a) Minimizing data redundancy
b) Achieving data independence
c) Both (a) and (b)
d) None of these.
xi) Phylogenetic relationship can be shown by
a) Dendogram b) Data search tool
c) Data retrieving d) Gene bank.
xii) Proteomics research can be categorized as
a) structural proteomics & functional proteomics
b) structural functional & comparative functional
c) functional & comparative proteomics
d) none of these.
GROUP – B
( Short Answer Type Questions )
Answer any three of the following. [Marks 3 × 5 = 15]
2. Define WWW, HTTP, HTML, URL.
3. What is substitution matrix ? Write down the difference
between PAM & BLOSUM matrix. [Marks 2 + 3]
4. What is sequence alignment ? Write about E value & Z score. [Marks 2 + 3]
5. Write down the difference between FASTA & BLAST. [Marks 2 + 3]
6. Write about data retrieval tool. What is sequin & bankit ? [Marks 2 + 3]
GROUP – C
( Long Answer Type Questions )
Answer any three of the following. [Marks 3 × 15 = 45]
7. a) What is Secondary Database ? Name two Secondary
Databases.
b) What is the difference between Accession Number and
Gi Number ?
c) What are the basis of database searching in
bioinformatics ?
d) What do you mean by BankIT ? [Marks 1 + 2 + 4 + 5 + 3]
8. a) Compare the features between Primary, Secondary and
Tertiary database.
b) What is PFAM and BLOCKS ?
c) Write down the differences between Flat File and
Hierarchical files.
d) Why Biological Database are important ? [Marks 5 + 3 + 4 + 3]
9. What is Dynamic Programming ? What are the general steps
of it ? Name two database searching tools. Fill the matrix for
DP and align the following sequences :
GAATTCAGTTA (sequence#1) (Upto Matrix fill step only)
GGATCGA (sequence#2) [Marks 2 + 1 + 2 + 7 + 3]
10. What is substitution matrix ? In "PAM 250" the 250 stands
for what ? Write down the difference of PAM 250 and
BIOSSM 62 matrix. What is humming and levenstein
distance ? Write down one name of two small molecule
database. What is Pubmed ? What is the name of the
database where you get the inheritable disease of human ?
What is word size ? Comment on sensitivity and selectivity ?
[Marks 1 + 1 + 3 + 4 + 1 + 1 + 1 + 1 + 2]
11. State the difference between homology and similarity ? Write
down 6 emerging fields in bioinformatics. You have given a
sequence of African elephant and Indian elephant how would
you draw the phylogenetic relation between them ? What
would you expect the result. What is relative mutability ? [Marks 3 + 3 + 4 + 2 + 3]
=============..
0 comments:
Pen down your valuable important comments below