University:West Bengal University of Technology
Course: B.Sc
Subject : MEDICAL MOLECULAR BIOLOGY
Year of Question Paper : 2012
CS/B.Sc.(H)MOLBIO/SEM-6/MMB-602/2012
2012
MEDICAL MOLECULAR BIOLOGY
Time Allotted : 3 Hours Full Marks : 70
The figures in the margin indicate full marks.
Candidates are required to give their answers in their own words as
far as practicable.
GROUP – A
( Multiple Choice Type Questions )
1. Choose the correct alternatives for any ten of the following :
10 × 1 = 10
i) Which year National Institute of Health took lead in
recombinant DNA ( rDNA ) research regulation ?
a) 1970 b) 1974
c) 1980 d) 1985.
ii) In which year did Dr. Martin Cline perform first DNA
transfer into bone marrow cells ?
a) 1975 b) 1980
c) 1982 d) 1987.
iii) In which year US Office of Technology Assessment
stressed the difference between somatic and germ-line
therapy ?
a) 1982 b) 1984
c) 1987 d) 1989.
iv) In which year did NIM perform the first approved gene
therapy procedure ?
a) 1985 b) 1990c) 1997 d) 2003.
v) Some cells of blastocyst ( 5 to 14 days ) are known as
a) Totipotent b) Pluripotent
c) Multipotent d) None of these.
vi) Cells differentiated, but can form a number of other
tissues are known as
a) Pluripotent b) Multipotent
c) Totipotent d) None of these.
vii) Which novel therapeutic molecule treats human
disease ?
a) miRNAs b) antisenseRNAs
c) shRNAs d) siRNAs.
viii) Genetic Locus Repetitive Behaviours of Autism are
discovered on chromosome
a) 10 b) 15
c) 18 d) 22.
ix) The proteins encoded by proto-oncogenes participated
in various metabolic processes including
a) Regulation of transcription
b) Cell-to-cell signalling
c) Intracellular signalling transduction
d) All of these.
x) CDK4/6-Cyclin D is the CDK-Cyclin complex of
a) G1 Phase of cell cycle b) G2 Phase of cell cycle
c) S Phase of cell cycle d) M Phase of cell cycle.
xi) Jun and Fos oncogenes are
a) G proteins b) Protein kinases
c) Transcription factors d) Cell receptors.
xii) Retinoblastoma is a tumor suppressor protein
and is
directly involved in
a) Transmission of extracellular signals to the nucleus
b) Cell cycle progression
c) Cytoskeletal rearrangement
d) General inhibition of various oncoproteins.
GROUP – B
( Short Answer Type Questions )
Answer any three of the following. 3 × 5 = 15
2. Define the role of Oncogenes in cancer.
3. Explain the role of polymer vectors in Gene Therapy.
4. Describe the role of Dopamine pathways in Human Brain
System.
5. Why is adult stem cell therapy getting preference over other
approaches of Gene therapy ?
6. What is therapeutic cloning ? How is it used in clinical
practice ?
GROUP – C
( Long Answer Type Questions )
Answer any three of the following. 3 × 15 = 45
7. Define Genetic causes of Breast Cancer. What is the
inheritance pattern of Breast Cancer ? What is the Molecular
Diagnostic Test ? What would be Genetic counselling to an
affected family ? 3 + 3 + 5 + 4
8. What are non-viral vectors in Gene Therapy ? Describe
various approaches of non-viral vectors delivery. What are
the major barriers of DNA delivery ? 3 + 6 + 6
9. Describe the critical period of Human Brain development.What are the factors essential for
development of Brain ?
6 + 9
10. What is Autism ? What are the typical features observed in
autistic behaviour ? Describe the evidences of genetic
factors involved. 3 + 5 + 7
11. Describe the mechanism leading to loss of Hetrozygosity in
Cancer. Write few names of dominantly inherited cancer
syndromes and recessive inherited cancer syndrome. 8 + 7
==========
Course: B.Sc
Subject : MEDICAL MOLECULAR BIOLOGY
Year of Question Paper : 2012
CS/B.Sc.(H)MOLBIO/SEM-6/MMB-602/2012
2012
MEDICAL MOLECULAR BIOLOGY
Time Allotted : 3 Hours Full Marks : 70
The figures in the margin indicate full marks.
Candidates are required to give their answers in their own words as
far as practicable.
GROUP – A
( Multiple Choice Type Questions )
1. Choose the correct alternatives for any ten of the following :
10 × 1 = 10
i) Which year National Institute of Health took lead in
recombinant DNA ( rDNA ) research regulation ?
a) 1970 b) 1974
c) 1980 d) 1985.
ii) In which year did Dr. Martin Cline perform first DNA
transfer into bone marrow cells ?
a) 1975 b) 1980
c) 1982 d) 1987.
iii) In which year US Office of Technology Assessment
stressed the difference between somatic and germ-line
therapy ?
a) 1982 b) 1984
c) 1987 d) 1989.
iv) In which year did NIM perform the first approved gene
therapy procedure ?
a) 1985 b) 1990c) 1997 d) 2003.
v) Some cells of blastocyst ( 5 to 14 days ) are known as
a) Totipotent b) Pluripotent
c) Multipotent d) None of these.
vi) Cells differentiated, but can form a number of other
tissues are known as
a) Pluripotent b) Multipotent
c) Totipotent d) None of these.
vii) Which novel therapeutic molecule treats human
disease ?
a) miRNAs b) antisenseRNAs
c) shRNAs d) siRNAs.
viii) Genetic Locus Repetitive Behaviours of Autism are
discovered on chromosome
a) 10 b) 15
c) 18 d) 22.
ix) The proteins encoded by proto-oncogenes participated
in various metabolic processes including
a) Regulation of transcription
b) Cell-to-cell signalling
c) Intracellular signalling transduction
d) All of these.
x) CDK4/6-Cyclin D is the CDK-Cyclin complex of
a) G1 Phase of cell cycle b) G2 Phase of cell cycle
c) S Phase of cell cycle d) M Phase of cell cycle.
xi) Jun and Fos oncogenes are
a) G proteins b) Protein kinases
c) Transcription factors d) Cell receptors.
xii) Retinoblastoma is a tumor suppressor protein
and is
directly involved in
a) Transmission of extracellular signals to the nucleus
b) Cell cycle progression
c) Cytoskeletal rearrangement
d) General inhibition of various oncoproteins.
GROUP – B
( Short Answer Type Questions )
Answer any three of the following. 3 × 5 = 15
2. Define the role of Oncogenes in cancer.
3. Explain the role of polymer vectors in Gene Therapy.
4. Describe the role of Dopamine pathways in Human Brain
System.
5. Why is adult stem cell therapy getting preference over other
approaches of Gene therapy ?
6. What is therapeutic cloning ? How is it used in clinical
practice ?
GROUP – C
( Long Answer Type Questions )
Answer any three of the following. 3 × 15 = 45
7. Define Genetic causes of Breast Cancer. What is the
inheritance pattern of Breast Cancer ? What is the Molecular
Diagnostic Test ? What would be Genetic counselling to an
affected family ? 3 + 3 + 5 + 4
8. What are non-viral vectors in Gene Therapy ? Describe
various approaches of non-viral vectors delivery. What are
the major barriers of DNA delivery ? 3 + 6 + 6
9. Describe the critical period of Human Brain development.What are the factors essential for
development of Brain ?
6 + 9
10. What is Autism ? What are the typical features observed in
autistic behaviour ? Describe the evidences of genetic
factors involved. 3 + 5 + 7
11. Describe the mechanism leading to loss of Hetrozygosity in
Cancer. Write few names of dominantly inherited cancer
syndromes and recessive inherited cancer syndrome. 8 + 7
==========
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