MEDICINAL CHEMISTRY – I,University Of Pune Question Paper,Third Year B.Pharmacy,2013 Question Paper

University Of Pune Question Paper
Third Year B.Pharmacy Examination, 2013
MEDICINAL CHEMISTRY – I
 3.3 : (2008 Pattern)
Time : 3 Hours Max. Marks : 80
 Note : 1) All questions are compulsory.
2) Correct structures and neat diagrams must be drawn
wherever necessary.
3) Answers to the two sections should be written in
separate books.
4) Figures to right indicate full marks.
SECTION – I
I. Solve any one :
a) Differentiate the parasympathetic receptor types with respect to their location,
pharmacological responses, therapeutic uses of agonist and antagonist of
each. 10
b) What are Antihypertensive agents ? Discuss the SAR, MOA of Beta blockers. 10
II. Solve any five : 15
1) Discuss the SAR, MOA of Potassium sparing diuretics.
2) Outline the synthesis of Guanethidine.
3) Enlist the physicochemical parameters responsible for drug absorption and
distribution in the biological system.
4) Explain Fergussion principle.
5) Outline the synthesis of Dicyclomine Hydrochloride.
6) Give the structure, IUPAC name and uses of Atenolol and Hydrochlorthiazide.
7) Write the SAR and MOA for ACE inhibitors.
P.T.O.
Seat
No.
[4355] – 303 -2-
III. Write short notes (any three) : 15
i) Types of receptors
ii) Antianginal drugs
iii) Antihyperlipidemic agents
iv) Alpha receptor antagonists
v) Calcium channel blockers
SECTION – II
IV. Solve any one :
a) Discuss the SAR, MOA of Phenothiazine derivatives. 10
b) Discuss in detail Insulin therapy and the SAR, MOA of Hypoglycemic agents. 10
V. Solve any five : 15
1) Outline the synthesis of Haloperidol.
2) Discuss in brief anxiolytic agents.
3) Outline the synthesis of Amitriptyline.
4) Discuss the SAR and MOA of nonselective reuptake inhibitors.
5) Give the structure, IUPAC nomenclature, synthesis of Diazepam.
6) Discuss in brief the SAR and MOA of GABA analogs.
7) Write in brief about Local anaesthetics.
VI. Write short notes (any three) : 15
a) General Anaesthetics
b) Drugs for treatment of Parkinsonism
c) Barbiturates
d) Analeptics
e) Alzeimer disease.
———————
B

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