Dr. MGR University MAY 2011 Question Paper
Subject :PAPER III ADVANCED MEDICINAL CHEMISTRY
[KY 345] Sub. Code: 2906M.PHARM. DEGREE EXAMINATION
(Regulations 2010)
(For candidates admitted from 2010-2011 onwards)
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER III – ADVANCED MEDICINAL CHEMISTRY
Q.P. Code : 262906
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (6 x 10 = 60)
1. Explain the role of G-Protein Coupled Receptor in the Cell Signaling Pathway.
2. What is meant by Analog Design?
Explain in detail Bioisoteric Replacements and Rigid Analogs.
3. Discuss the various physico-chemical parameters that affect biological activity.
4. Explain how enzyme inhibitors are used against microorganisms and the body’s
own enzymes to produce effective therapeutic agents. Give examples.
5. Outline the synthesis of Omeprazole and Clonidine.
6. Discuss the importance of enantio selectivity in drug absorption , metabolism,
distribution and elimination.
II. Write notes on : (8 x 5 = 40)
1. Outline the steps involved in the manufacture of Pheniramine Maleate.
2. Explain the mechanism of action of intercalating agents.
3. Explain Craig Plot.
4. Give five applications of Pro-drug design with suitable examples.
5. Inhibitors of viral reverse transcriptase.
6. Monte Carlo method of conformational Analysis.
7. Interferons.
8. Explain how proton pump inhibitors act.
*******
Dr. MGR University OCTOBER 2011 Question Paper
Subject :PAPER III ADVANCED MEDICINAL CHEMISTRY
[KZ 345] Sub. Code: 2906M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER III – ADVANCED MEDICINAL CHEMISTRY
Q.P. Code : 262906
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. a) Discuss the various stearic substituent constants
commonly used in QSAR. Explain the effect of stearic 17 40 min. 20
and electromeric parameters on lipophilicity.
b) Classify antiviral agents. Explain the mechanism of action
and synthesis of one drug form 2 different classes.
2. Define Prodrug. Elaborate various types of prodrug design
with suitable example. 17 40 min. 20
II. Write notes on :
1. Pyrimidine antimetabolites. 4 10 min. 6
2. Manufacturing process of Diphenhydramine. 4 10 min. 6
3. Enantio-selectivity in drug absorption. 4 10 min. 6
4. Immuno response. 4 10 min. 6
5. Design of enzyme inhibitors as drugs. 4 10 min. 6
6. Molecular mechanics in molecular modeling. 4 10 min. 6
7. Gastric acid secretion and its inhibitors. 4 10 min. 6
8. Antihypertensive agents. 4 10 min. 6
9. How does rigid analog and alteration of chain branching
help in Analog design. 4 10 min. 6
10. What are Prostaglandins? How are they useful in the
design of new drugs? 4 10 min. 6
*******
Dr. MGR University MAY 2012 Question Paper
Subject :PAPER III ADVANCED MEDICINAL CHEMISTRY
[LA 345] Sub. Code: 2906M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER III – ADVANCED MEDICINAL CHEMISTRY
Q.P. Code : 262906
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. a) Explain the analog design and detail on bioisosteric
replacement with examples. 17 40 min. 20
b) Discuss the rational of prodrug design and practical
consideration.
2. a) Explain the importance of enantio selectivity in
drug absorption, metabolism, distribution and elimination. 17 40 min. 20
b) Write briefly about gastric proton pump inhibitors.
II. Write notes on:
1. Explain the chemistry and biological significance of
prostaglandins. 4 10 min. 6
2. Explain 3D QSAR approaches. 4 10 min. 6
3. Give detailed account of alkylating agents as anti-neoplastic drugs. 4 10 min. 6
4. Write briefly on Quantum mechanism. 4 10 min. 6
5. Write a note on immuno stimulants. 4 10 min. 6
6. Outline the Steps involved in the manufacture of
Diphenhydramine. 4 10 min. 6
7. Write a note on covalently binding enzyme inhibitors. 4 10 min. 6
8. Discuss about drug receptor interactions. 4 10 min. 6
9. Explain pharmacophore models. 4 10 min. 6
10. Give the application of Craig plot. 4 10 min. 6
*******
Dr. MGR University OCTOBER 2012 Question Paper
Subject :PAPER III ADVANCED MEDICINAL CHEMISTRY
[LB 345] Sub. Code: 2906M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER III – ADVANCED MEDICINAL CHEMISTRY
Q.P. Code : 262906
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. a) Describe the medicinal aspects and SAR of alkylating agents. 17 40 min. 20
b) Describe the types of drug receptor interactions.
2. a) Describe various concepts involved in quantum mechanics. 17 40 min. 20
b) Explain various stereochemical aspects involved in drug action.
II. Write Notes on :
1. Describe various physicochemical parameters involved in
QSAR studies. 4 10 min. 6
2. Explain the medicinal chemistry aspects of reverse transcriptase
inhibitors as antiviral agents. 4 10 min. 6
3. Write a note on the manufacture of pheniramine maleate. 4 10 min. 6
4. Explain the design of covalently binding enzyme inhibitors. 4 10 min. 6
5. Explain the mechanism involved in gastric acid secretion. 4 10 min. 6
6. Explain the pharmacokinetic and biopharmaceutical aspects of
prodrug design. 4 10 min. 6
7. Explain the rigid analog design strategy in analog design. 4 10 min. 6
8. Write a note on the medicinal applications of prostaglandins. 4 10 min. 6
9. Write a note on immune modulators. 4 10 min. 6
10. Briefly explain the medicinal aspects of Angiotensin converting
enzyme inhibitors. 4 10 min. 6
*******
Dr. MGR University APRIL 2013 Question Paper
Subject :PAPER III ADVANCED MEDICINAL CHEMISTRY
[LC 345] Sub. Code: 2906M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER III – ADVANCED MEDICINAL CHEMISTRY
Q.P. Code : 262906
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
1. a) Write in detail accounts QSAR models.
b) Classify the covalently binding enzyme inhibitors with example.
2. a) Define analog design .
Explain in detail rigid analog and fragments of leads molecule.
b) Discuss the various test assays for studying gastric acid inhibition.
II. Write notes on : (10 x 6 = 60)
1. Outline the steps involved in the manufacture of the sulphamethoxazole.
2. Classify Antihypertensive drugs and explain the mechanism of ACE inhibitors.
3. Write a note on immune response.
4. Write briefly on known receptors sites on molecular modeling.
5. Discuss the role of chirality in the receptors and specific therapeutic agents.
6. Writes briefly about drugs receptors interactions.
7. Give the application of Hansch analysis.
8. Explain pharmacophore models.
9. Writes a note on regression analysis and partial least square analysis.
10. Explain the biological significance of leukotrienes.
*******
Dr. MGR University OCTOBER 2013 Question Paper
Subject :PAPER III ADVANCED MEDICINAL CHEMISTRY
[LD 345] Sub. Code: 2906M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER III – ADVANCED MEDICINAL CHEMISTRY
Q.P. Code : 262906
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
1. a) Describe in details about receptor types and sub types.
b) Classify antihypertensive drugs with examples.
Give the mechanism of action and synthesis of one drug form two different classes.
2. a) Define prodrug.
Explain with examples the different aspects of prodrugs in drug designing.
b) Discuss in detail about different approaches in drug design from lead molecule.
II. Write notes on : (10 x 6 = 60)
1. Hansch analysis in QSAR studies.
2. Molecular mechanics.
3. 3D QSAR approaches in drug design.
4. How partition coefficient affect the biological activity of a drug with example
5. Enzyme inhibitors in basic research.
6. Role of chirality in selective and specific therapeutic agents.
7. Method of manufacture of paracetamol.
8. Irreversible gastric proton pump inhibitors.
9. Immuno stimulants.
10. Synthesis and mode of action of anti viral agent.
*******
Dr. MGR University APRIL 2014 Question Paper
Subject :PAPER III ADVANCED MEDICINAL CHEMISTRY
[LE 345] Sub. Code: 2906M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER III – ADVANCED MEDICINAL CHEMISTRY
Q.P. Code : 262906
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
1. a) Discuss in detail about drug receptor interaction.
b) Classify antineoplastic agents with examples.
Give the mode of action and synthesis of one drug form two different classes.
2. a) Explain the rational design of covalently binding enzyme inhibitors.
b) Explain the importance of prodrug design with suitable examples.
II. Write notes on : (10 x 6 = 60)
1. Merits and demerits of Hansch analysis and Free Wilson analysis.
2. Pharmacophore models in drug design.
3. Mechanism of action and synthesis of ACE inhibitors.
4. Enantio selectivity in the distribution of drugs.
5. Industrial method of manufacture of indomethacin.
6. How bio-isosterism effects the biological activity of drugs.
7. Immuno suppressants.
8. Various approaches of drug design from lead molecule
9. Gastric proton pump inhibitors.
10. Regression analysis and partial least square analysis.
*******
Dr. MGR University OCTOBER 2014 Question Paper
Subject :PAPER III ADVANCED MEDICINAL CHEMISTRY
[LF 345] Sub. Code: 2906M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER III – ADVANCED MEDICINAL CHEMISTRY
Q.P. Code : 262906
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
1. a) Explain the biosynthesis of Prostaglandins.
b) Give the mechanism of action of prostaglandins.
c) Write a note on clinically approved prostaglandins.
2. Explain (with case study) the role of chirality in drug absorption, metabolism,
distribution and elimination.
II. Write notes on : (10 x 6 = 60)
1. Explain the SAR, mechanism of action and synthesis of irreversible proton pump
inhibitors.
2. What do you mean by 3D QSAR? Write a short note on CoMFA.
3. What is IC50?
Give the general mechanism of reversible and irreversible enzyme inhibitors.
4. Explain the method of manufacture of sulphamethoxazole.
5. Explain briefly the various forces involved in the non-covalently binding enzyme
inhibitors.
6. Explain the disorders associated with elevated gastric acid secretions.
7. Give the structure and synthesis of following:
a) Nifedipine b) Prazosin c) Hydralazine.
8. What is immune response? Discuss briefly about immuno-stimulants.
9. How does prodrug help to overcome the pharmacokinetic problems associated
with the drug discovery process?
10. Antiviral agents
*******
Dr. MGR University APRIL 2015 Question Paper
Subject :PAPER III ADVANCED MEDICINAL CHEMISTRY
[LG 345] Sub. Code: 2906M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH II – PHARMACEUTICAL CHEMISTRY
PAPER III – ADVANCED MEDICINAL CHEMISTRY
Q.P. Code : 262906
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
1. Explain in detail various strategies utilized in analog design.
2. Briefly explain the medicinal chemistry aspects of antihypertensive agents with special
emphasis to classification, mechanism of action, structure and synthesis of any one
drug from each class.
II. Write notes on : (10 x 6 = 60)
1. Briefly account on molecular mechanics in molecular modeling.
2. Write a note on steric factors in a QSAR study.
3. Write a brief note on pharmacophore models.
4. Briefly explain the manufacture of Paracetamol.
5. Describe in detail about the biosynthesis of prostaglandins.
6. Outline various approaches in prodrug design.
7. Write a note on antineoplastic antimetabolites.
8. Describe various theories involved in drug receptor interactions.
9. Outline the aspects of enantioselectivity in drug absorption and elimination.
10. Briefly explain with examples on noncovalent enzyme inhibitors.
*******
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