Dr. MGR University 2011 -2015 Question Papers PAPER II PHARMACOLOGY AND TOXICOLOGY

Dr. MGR University MAY 2011 Question Paper
Subject : PAPER II – PHARMACOLOGY AND TOXICOLOGY

[KY 350] Sub. Code: 2911
M.PHARM. DEGREE EXAMINATION
(Regulations 2010)
(For candidates admitted from 2010-2011 onwards)
FIRST YEAR
BRANCH IV – PHARMACOLOGY
PAPER II – PHARMACOLOGY AND TOXICOLOGY
Q.P. Code : 262911
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (6 x 10 = 60)
 1. Explain the pharmacological importance of “plasma protein binding”.
 2. Enumerate the various principles of drug action.
 3. Explain the role of excitatory neurotransmitters and inhibitory neurotransmitters in
 the synaptic transmission.
 4. Enumerate the various inflammatory mediators.
 5. Explain the mechanism and mode of action of digitalis in congestive heart failure.
 6. Outline the four classes of hypersensitive reactions.
II. Write notes on : (8 x 5 = 40)
 1. Write the mode of action of diuretics in hypertension.
 2. Write the mode of action of beta blockers in angina.
 3. Write the mode of action of phenylpropanalomine in common cold.
 4. Enumerate the role of prostaglandins in gastrointestinal tract.
 5. Write the mode of action of steroidal drugs in asthma.
 6. Explain briefly the two uses of prokinetics.
 7. Explain briefly the two uses of antihistamines.
 8. Explain briefly about the development of bacterial resistance to antimicrobials.
*******

Dr. MGR University OCTOBER 2011 Question Paper
Subject : PAPER II – PHARMACOLOGY AND TOXICOLOGY

[KZ 350] Sub. Code: 2911
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV – PHARMACOLOGY
PAPER II – PHARMACOLOGY AND TOXICOLOGY
Q.P. Code : 262911
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
 1. a) Discuss the absorption of drugs.
 What are the factors affecting drugs absorption? 17 40 min. 20
 b) Explain the influence of pH and partition co-efficient
 on drug absorption.
 c) Explain briefly how drugs are absorbed from various routes.
 2. a) What are catecholamines? Classify sympathomimetic drugs. 17 40 min. 20
 b) Discuss the pharmacology of Amphetamine.
 c) Write a note on Dale’s vasomotor reversal.
II. Write notes on :
 1. Explain the synthetic reactions of biotransformation. 4 10 min. 6
 2. Describe briefly peripherally acting skeletal muscle relaxant. 4 10 min. 6
 3. Define Glaucoma, and drugs used for Glaucoma. 4 10 min. 6
 4. Explain drugs interaction with the help of examples. 4 10 min. 6
 5. Note on Hypolipidemic drugs. 4 10 min. 6
 6. Explain the treatment of Thrombolytic. 4 10 min. 6
 7. Explain Alcohol and treatment of alcohol poisoning. 4 10 min. 6
 8. What are the different phases of clinical trials? 4 10 min. 6
 Describe the all phase. 4 10 min. 6
 9. Mechanism of action and uses of ACE inhibitors. 4 10 min. 6
10. Discuss detail about treatment of Migraine. 4 10 min. 6
*******

Dr. MGR University MAY 2012 Question Paper
Subject : PAPER II – PHARMACOLOGY AND TOXICOLOGY

[LA 350] Sub. Code: 2911
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV – PHARMACOLOGY
PAPER II – PHARMACOLOGY AND TOXICOLOGY
Q.P. Code : 262911
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
 1. a) Discuss the drugs for Neurodegenerative diseases. 17 40 min. 20
 b) Classify Anti-parkinsonism drugs. Explain pharmacology
 of Levodopa.
 c) Write a note on decarboxylase inhibitors synergism.
 2. a) Classify Anti-hypertensive drugs. Discuss the systemic 17 40 min. 20
 pharmacology of Angiotension II receptor blockers.
 b) Describe the calcium channel blockers.
 c) Write a note on treatment of Hypertension.
II. Write notes on:
 1. Factors affecting drugs metabolism. 4 10 min. 6
 2. Explain how Aspirin acts as a anti platelet agent. 4 10 min. 6
 3. Explain about MAO inhibitors with examples. 4 10 min. 6
 4. Describe the Bioavailability and Bioequivalence of drugs. 4 10 min. 6
 5. Write a note on Prokinetic agent. 4 10 min. 6
 6. Classify oral hypoglycemic agents with examples. 4 10 min. 6
 7. Explain about Eicosanoides. 4 10 min. 6
 8. Mast cell stabilizers. 4 10 min. 6
 9. Describe detailly about Drug dependence and addiction. 4 10 min. 6
10. Describe the structural and functional aspects of receptors. 4 10 min. 6
*******

Dr. MGR University OCTOBER 2012 Question Paper
Subject : PAPER II – PHARMACOLOGY AND TOXICOLOGY

[LB 350] Sub. Code: 2911
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV – PHARMACOLOGY
PAPER II – PHARMACOLOGY AND TOXICOLOGY
Q.P. Code : 262911
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
 1. Define antibiotics. 17 40 min. 20
 Explain the general mechanisms of action of various antibiotics.
 Explain the various ways by which the organisms develop
 antibiotic resistance.
 2. Define congestive heart failure. 17 40 min. 20
 Classify drugs used to treat congestive heart failure.
 Explain the mechanism of action, pharmacological effects,
 therapeutic indications and toxicity of digitalis.
II. Write Notes on :
 1. Factors affecting biotransformation of drugs. 4 10 min. 6
 2. Pharmacogenetics. 4 10 min. 6
 3. Synthesis and degradation of catecholamines. 4 10 min. 6
 4. Pharmacological actions of morphine. 4 10 min. 6
 5. Metronidazole. 4 10 min. 6
 6. Calcium channel blockers. 4 10 min. 6
 7. Phenytoin. 4 10 min. 6
 8. Tachyphylaxis. 4 10 min. 6
 9. General methods of treating poison. 4 10 min. 6
10. Generation of free radicals. 4 10 min. 6
*******

Dr. MGR University APRIL 2013 Question Paper
Subject : PAPER II – PHARMACOLOGY AND TOXICOLOGY

[LC 350] Sub. Code: 2911
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV – PHARMACOLOGY
PAPER II – PHARMACOLOGY AND TOXICOLOGY
Q.P. Code : 262911
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. a) Classify NSAID’S with examples.
 Discuss the Mechanism of action and Therapeutic uses of NSAID’S.
 b) Enumerate the various inflammatory mediators.
 2. a) Define cancer chemotherapy and classify chemotherapeutic agents.
 b) Describe briefly about Anti metabolites of drugs.
 c) Write a note on Radioactive isotopes.
II. Write notes on : (10 x 6 = 60)
 1. Concept of hepatic and renal clearance.
 2. Explain the plasma proteins binding of drugs.
 3. Discuss about Immunosuppressant drugs.
 4. Classify and mention the pharmacology of Benzodiazepines with one example.
 5. Drugs for Anti-emetics.
 6. Write a note on Histamine and explain about H1 antagonists.
 7. Describe detailly mechanisms of Anti-bodies and give related examples of each
 mechanism.
 8. Explain the Tachyphylaxis and give the examples of the drugs.
 9. Describe the regulatory bodies in clinical pharmacology.
10. Write about Therapeutic drugs monitoring of Digoxin.
*******

Dr. MGR University OCTOBER 2013 Question Paper
Subject : PAPER II – PHARMACOLOGY AND TOXICOLOGY

[LD 350] Sub. Code: 2911
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV – PHARMACOLOGY
PAPER II – PHARMACOLOGY AND TOXICOLOGY
Q.P. Code : 262911
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. Explain the general principles of neurotransmission.
 Describe the steps involved in cholinergic neurotransmission and discuss about the
 various drugs affecting the same.
 2. a) Describe the insulin receptor and discuss the mechanism of action of insulin.
 b) Classify oral hypoglycaemic agents.
 Explain the pharmacology of insulin secretagogues.
II. Write notes on : (10 x 6 = 60)
 1. Cytochrome P 450 enzyme system.
 2. Drug-drug interactions.
 3. Clonidine.
 4. Opioid peptides.
 5. Anti-emetic drugs.
 6. Mechanism and therapeutic uses of benzodiazepines.
 7. Oral anticoagulants.
 8. Class II antiarrhythmic agents.
 9. Mechanisms involved in tachyphylaxis.
10. Clinical trial designs.
*******

Dr. MGR University APRIL 2014 Question Paper
Subject : PAPER II – PHARMACOLOGY AND TOXICOLOG

[LE 350] Sub. Code: 2911 

M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV – PHARMACOLOGY
PAPER II – PHARMACOLOGY AND TOXICOLOGY
Q.P. Code : 262911
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. a) Define the term biotransformation and explain phase II metabolic reactions.
 b) Discuss the mechanism of metabolism induction and inhibition citing examples
 2. Classify antibiotics based on their site of action with examples.
 Describe the mechanism of action, spectrum of activity and therapeutic use of
 cefuroxime. What is the use of clavulanic acids?
II. Write notes on : (10 x 6 = 60)
 1. Explain the influence of ph and partition coefficient on drug absorption.
 2. Write the physiological role and consequences of deficiency of Superoxide Desmutase.
 3. Classify skeletal muscle relaxants. Describe the mechanism of action of gallamine.
 4. Classify drugs used in the treatment of bronchial asthma with example.
 5. Explain about MAO inhibitors with example.
 6. Write notes on mast cell stabilizers.
 7. Describe angina pectoris and write short notes on vasodilators.
 8. Describe about the action of HMG-Co A reductase inhibitors.
 9. Describe the management of heavy metal poisoning.
10. Write notes on treatment of migraine.
*******

Dr. MGR University OCTOBER 2014 Question Paper
Subject : PAPER II – PHARMACOLOGY AND TOXICOLOG

[LF 350] Sub. Code: 2911
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV – PHARMACOLOGY
PAPER II – PHARMACOLOGY AND TOXICOLOGY
Q.P. Code : 262911
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. Define bioavailability. Explain the various factors affecting bioavailability.
 Describe the importance of bioequivalence studies.
 2. What is congestive heart failure? Classify the drugs used in congestive heart failure.
 Explain the mechanism of action, pharmacological actions, toxicity and therapeutic
 uses of digoxin.
II. Write notes on : (10 x 6 = 60)
 1. Membrane transporters.
 2. Hepatic clearance of drugs.
 3. Excitatory neurotransmitters in CNS.
 4. Mechanism of local anaesthetic agents.
 5. Cephalosporins.
 6. Angiotensin converting enzyme (ACE) inhibitors.
 7. Cyclooxygenase-2 (COX-2) inhibitors.
 8. Vasopressin.
 9. Free radicals.
10. Components of clinical trial protocol.
******

Dr. MGR University APRIL 2015 Question Paper
Subject : PAPER II – PHARMACOLOGY AND TOXICOLOG

[LG 350] Sub. Code: 2911
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH IV – PHARMACOLOGY
PAPER II – PHARMACOLOGY AND TOXICOLOGY
Q.P. Code : 262911
Time: Three Hours Maximum: 100 marks
Answer ALL questions
I. Elaborate on : (2 x 20 = 40)
 1. a) Define the term biotransformation and explain phase I metabolic reactions.
 b) Discuss the mechanism of induction and inhibition of drug metabolism.
 2. a) What is catecholamine? Discuss the systemic pharmacology of Epinephrine.
 b) Explain the drug treatment of glaucoma.
 c) Write a note on cholinesterase inhibitors.
II. Write notes on : (10 x 6 = 60)
 1. Explain the plasma protein binding and its pharmacological importance.
 2. What are the general aspects of receptor pharmacology?
 3. Explain the role of excitatory neurotransmitter in the synaptic transmission.
 4. What is mania? Explain the pharmacology of lithium carbonate.
 5. Outline the four classes of hypersensitive reactions.
 6. Explain the effect of Haematinics in blood constituents.
 7. Explain the insulin importance in Diabetes.
 8. Write a note on Cephalosporins.
 9. Describe the regulatory bodies in clinical pharmacology.
10. Explain about Eicosanoides.
******* 

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