Dr. MGR University OCTOBER 2011 Question Paper
Subject : PAPER II – PHARMACEUTICAL ANALYSIS
[KZ 814] Sub. Code: 3814DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS
Q.P. Code: 383814
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. Explain the theory of polarography involving Ilkovic equation,
dropping mercury electrode, current voltage curve, 17 40 min. 20
various current produced and its application in pharmacy.
2. Describe the theory of UV absorption spectroscopy and 17 40 min. 20
laws governing, deviation of laws.
Draw the diagram of a double beam UV spectrometer and
its application in single / multi component analysis.
II. Write notes on :
1. Write on theory, carrier gases and stationary phases
used in gas chromatography. 4 10 min. 6
2. Explicate the types of fluorescence quenching with examples
and give the application of fluorimetry to pharmaceuticals. 4 10 min. 6
3. What are the reference and indicator electrodes used
in potentiometric titrations. Explain construction, 4 10 min. 6
working and advantages of one electrode from each of the type.
4. What are the basic components of a HPTLC instrument?
Explain the advantages and application of HPTLC in pharmacy. 4 10 min. 6
5. What are the vibrations occur in a molecule on IR absorption?
Give the elements of interpretation of an IR spectrum of a molecule. 4 10 min. 6
6. Explain the concepts of statistical quality control. 4 10 min. 6
7. What is conductometric titration? Explain them with suitable
examples. 4 10 min. 6
8. Write on construction, working principle and advantages of a
flame ionization detector used in gas chromatography. 4 10 min. 6
9. Explain the ion exchange mechanism and
write on various factors affecting ion exchange process. 4 10 min. 6
10. Briefly write on the procedure of regulatory control. 4 10 min. 6
*******
Dr. MGR University APRIL 2012 Question Paper
Subject : PAPER II – PHARMACEUTICAL ANALYSIS
[LA 814] Sub. Code: 3814DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS
Q.P. Code: 383814
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. Explain the theory of IR absorption?
Draw and label IR spectrometer giving details on its components. 17 40 min. 20
How is IR spectroscopy applied for qualitative and quantitative
analysis of pharmaceuticals.
2. Write the theoretical aspects, indicator and reference
electrodes used, and measurement of pH, types of titrations 17 40 min. 20
and end point detection and application of potentiometry.
II. Write notes on :
1. What are the fundamental laws governing UV absorption
and why do molecules deviate from laws? 4 10 min. 6
2. How does a good laboratory practice performed in an industry? 4 10 min. 6
3. Elaborate on theory of fluorescence. How does a
pharmaceutical compound estimated by fluorescence concept? 4 10 min. 6
4. What are amperometric titrations? Add note on advantages
and pharmaceutical applications of amperometric titrations. 4 10 min. 6
5. Give note on monochromators and detectors used in UV
spectrophotometers. 4 10 min. 6
6. Draw and label a double beam spectrofluorimeter giving its
advantage. 4 10 min. 6
7. How does the Derivatization and temperature
programming are used in gas chromatographic analysis. 4 10 min. 6
8. Describe the polarographic principle and factors
affecting polarographic measurements. 4 10 min. 6
9. What are the differences between atomic absorption
and flame emission spectroscopy? 4 10 min. 6
10. Give the principle and application of NMR and ESR spectroscopy. 4 10 min. 6
*******
Dr. MGR University OCTOBER 2012 Question Paper
Subject : PAPER II – PHARMACEUTICAL ANALYSIS
[LB 814] Sub. Code: 3814DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS
Q.P. Code: 383814
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
I. Elaborate on : Pages Time Marks
(Max.) (Max.) (Max.)
1. Explain the working with the help of a neat, labeled,
schematic block diagram of a HPLC and describes its 17 40 min. 20
operational modalities briefly. Write the advantages
and classification based on mode of separation of HPLC.
2. Discuss the underlying principle of Atomic Absorption Spectrometry
(AAS). Describe the various components that are essentially involved
in double beam AAS with help of a schematic diagram. How do the
following three types of interferences affect the atomic absorption
spectroscopic methods (a) Spectral interferences
(b) Chemical interferences (c) Ionisation interferences. 17 40 min. 20
II. Write notes on :
1. Express Beer-Lambert’s Law. Write its limitation,
application and deviation. 4 10 min. 6
2. a) Flame ionization detectors.
b) What are the various factors affect the separation. 4 10 min. 6
of compounds in column chromatography.
3. Discuss the typical conductrometric titration curves
obtained in conductrometric method of analysis and 4 10 min. 6
examine them critically with appropriate examples .
4. Write a note on: (a) Glass electrodes (b) Dropping Mercury
Electrons (DME). 4 10 min. 6
5. Spectrophometric titration. 4 10 min. 6
6. Sample handling in IR spectroscopy. 4 10 min. 6
7. What is Fluorescence? What are the various factors affecting
the fluorescence intensity? 4 10 min. 6
8. What is mass spectrum? Write its principle and different type
of ions produced in that. 4 10 min. 6
9. Write a note on DSC. 4 10 min. 6
10. What is validation? Give a brief account of validation of
analytical methods. 4 10 min. 6
*******
Dr. MGR University APRIL 2013 Question Paper
Subject : PAPER II – PHARMACEUTICAL ANALYSIS
[LC 814] Sub. Code: 3814DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS
Q.P. Code: 383814
Time: Three Hours Maximum: 100 marks
Answer All questions
I. Elaborate on: (2 x 20 = 40)
1. Explain the working and components of gas chromatograph with help of a neat,
labeled, schematic block diagram. Write a note on classification, principle, factors
influencing the separation and criteria to perform the Gas chromagraphy.
2. a) Draw an UV-Visible double beam spectrophotometer with a neat, labeled,
block diagram and explain its each component operational mode.
b) Why a double beam spectrophotometer gives more precise, reliable
and reproducible results in comparison to a single beam spectrophotometer?
c) What are the factors influencing the absorption of radiant energy?
II. Write notes on: (10 x 6 = 60)
1. Give a brief and comprehensive account of application of conductometry?
2. State Bcer-Lambert’s law. Derive it Write its application, deviation and limitation.
3. Discuss the underlying principle and interfecrence of atomic absorption spectrometry.
4. Name the detectors used in HPLC. Discuss anyone the of them.
5. Differentiate validation and calibration. Give a brief account of validation of
analytical methods.
6. Explain the theory and procedure of DSC.
7. Discuss the fundamental theory of mass spectroscopy.
What are the different ions produced in mass spectrum?
8. What is quenching? What are different type of quenching?
Write a note on factors affecting the fluorescence intensity.
9. Explain the various method of sample handling in IR-Spectroscopy.
10. Give a brief account of :
a) Indicator electrode, b) Polarzable electrode, c) Spectrophotometric titration.
*******
Dr. MGR University OCTOBER 2013 Question Paper
Subject : PAPER II – PHARMACEUTICAL ANALYSIS
[LD 814] Sub. Code: 3814DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS
Q.P. Code: 383814
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (2 x 20 = 40)
1. a) Explain the different electronic transitions involved in UV spectrophotometry
with examples.
b) Describe the theory and instrumentation of DSC.
2. a) Explain the principle and instrumentation of IR spectroscopy with a neat diagram.
b) Describe the theory and instrumentation of atomic absorption spectrometry.
II. Write notes on: (10 x 3 = 30)
1. Write a brief note on theoretical aspects of mass spectra.
2. Give a brief account on ICH guidelines.
3. What is ion-exchange chromatography?
List the different types of ion exchange resins used in ion-exchange chromatography.
4. List the detectors used in GLC.
Explain the principle of any one.
5. What is plane polarized light?
Define optical rotatory dispersion and circular dichroism.
6. Explain any three factors affecting the fluorescence intensity.
7. Explain the working principle of hydrogen electrode with a neat diagram.
8. Write a brief note on conductometric titrations.
9. Write a note on chemical shift.
10. Explain briefly the applications of flame photometry.
*******
Dr. MGR University APRIL 2014 Question Paper
Subject : PAPER II – PHARMACEUTICAL ANALYSIS
[LE 814] Sub. Code: 3814DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS
Q.P. Code: 383814
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (2 x 20 = 40)
1. a) With a neat labeled diagram, explain the principle and instrumentation of HPLC.
b) Write principle, stationary phase, mobile phase, development techniques and
applications of paper chromatography.
2. a) Describe the theory of IR absorption.
With a neat labeled diagram, explain the instrumentation of IR spectroscopy.
Explain its applications in qualitative analysis of pharmaceuticals.
b) Write the principle involved in NMR and Mass spectroscopy.
II. Write notes on: (10 x 3= 30)
1. Define chromophore, auxochrome and hypsochromic shift.
2. Write the applications of DSC and DTA in Pharmaceutical Analysis.
3. Define GLP, ICH and Validation.
4. What is base peak? List the different types ions produced in mass spectra.
5. List at least three differences between TLC and HPTLC.
6. Discuss briefly about ESR and its application.
7. Write the differences between flame emission and atomic absorption spectroscopy.
8. Define electrode potential. Give example of reference and indicator electrode
used in potentiometry.
9. What do you know about dropping mercury electrode?
Give any two advantages and disadvantages.
10. Write a brief note on quenching.
*******
Dr. MGR University APRIL 2015 Question Paper
Subject : PAPER II – PHARMACEUTICAL ANALYSIS
[LG 814] Sub. Code: 3814DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION
(2009-2010 Regulation)
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS
Q.P. Code: 383814
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (4 x 10 = 40)
1. With a neat labeled diagram, discuss the principle and various components of
IR spectroscopy.
2. Write the principle and various carrier gases used in GLC.
Explain working principle of any two detectors used in GLC with a neat labeled
diagram.
3. Explain the principle and instrumentation of spectrofluorimeter with a neat diagram.
4. Write the theoretical aspects, indicator and reference electrodes used, methods of
detecting end point in potentiometry.
II. Write notes on: (6 x 5 = 30)
1. State and explain fundamental laws of absorption.
Write its deviations and reasons for the deviations.
2. What are amperometric titrations?
Add a note on advantages and applications of amperometric titrations.
3. Write a note on DTA.
4. What is validation? Give a brief account of validation of analytical methods.
5. Describe the principle and various types of ion exchange resins used in ion exchange
chromatography.
6. Explain the principle involved in mass spectroscopy.
List the various types of ions produced in mass spectrum.
*******
Dr. MGR University OCTOBER 2015 Question Paper
Subject : PAPER II – PHARMACEUTICAL ANALYSIS
[LH 814] Sub. Code: 3814PHARM. D DEGREE EXAMINATION
(2009-2010 Regulation)
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS
Q.P. Code : 383814
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on : (4 x 10 = 40)
1. With a neat labeled diagram, explain the working principle and instrumentation
of HPLC.
2. Explain the principle and instrumentation of AAS.
3. Write in detail the theoretical aspects and applications of NMR.
4. What is thermal analysis? Explain the principle and instrumentation of DSC.
II. Write notes on : (6 x 5 = 30)
1. Explain in detail the various factors affecting fluorescence.
2. Write a note on monochromator and detectors used in UV spectrophotometer.
3. Describe the principle and applications of X-ray diffraction.
4. What are the basic components of HPTLC? Write the advantages and applications
of HPTLC.
5. Write a note on optical rotator dispersion and circular dichroism.
6. Explain the various sample handling techniques adopted in IR spectroscopy.
*******
0 comments:
Pen down your valuable important comments below