Dr.A.P.J.Abdul Kalam University
Bachelor of Pharmacy
Seventh Semester Main Examination, Dec-2020
Novel Drug Delivery System [BP704T]
Time: 3:00 Hrs Max Marks 75
Note : (i) All parts of the question paper are compulsory.
(ii) All question of each part to be attempt at one place.
Part-A
Q.1 Multiple choice questions- [1x20 = 20 Marks]
(i) Which of the following drugs cannot be given as transdermal administration-
(a) Drugs with very short half-life
(b) Drugs with narrow therapeutic indices
(c) Easy removal and termination
(d) Drugs against peptic ulcer
(ii) Which of the following characteristics is suitable for transdermal drug-
(a) Large drug dose
(b) Large molecular size
(c) Drugs with narrow therapeutic indices
(d) Drugs which are metabolized in the skin
(iii) What are the characteristics of the monolithic devices-
(a) The drug has a large therapeutic index
(b) Aqueous solutions
(c) Control drug release by partitioning the drug from the oil
(d) Administration of emulsions
(iv) The rate at which monolithic devices transfer drugs to the patient body is proportional to _______________
of time.
(a) Square of time
(b) The square root of time
(c) Twice the time
(d) Half the time
(v) What are the characteristics of the reservoir or membrane devices-
(a) The drug has a large therapeutic index
(b) Drug permeation rate is high
(c) Control drug release by partitioning the drug from the oil
(d) Administration of emulsions
(vi) What are the characteristics of the mixed monolithic-reservoir devices-
(a) The drug has a large therapeutic index
(b) Drug permeation rate is high
(c) The drug-polymer matrix is layered by rate-controlling membrane
(d) Administration of emulsions
(vii) The absorption of the ophthalmic drug does not depend on which of the following?
a) Physicochemical properties of the permeating molecule
b) Drainage of tears
c) Output of tears
d) Size of the eyeball
(viii) Which of the following is false in regarding reservoir devices?
a) These devices are used when the drug permeation rate is rapid
b) The release of the drug is controlled
c) Suitable for low therapeutic indices
d) The drug is contained in a powder form floating on liquid
(ix) Which of the following is true for monolithic devices?
a) These devices are used when the drug permeation rate is rapid
b) The release of the drug is controlled
c) Suitable for drugs with large therapeutic indices
d) The drug is contained in a powder form floating on liquid
(x) Which of the following is false for monolithic devices?
a) The drug used for these devices has large therapeutic indices
b) There are three categories of matrix devices
c) 1st type has the drug dissolved in the polymer matrix
d) 2nd type has drug dispersed
(xi) The four types of Artificial nanomaterials are __________
a) Carbon-based, non-metallic, composites and ceramics
b) Carbon-based, metallic, composites and ceramics
c) Carbon-based, non-metallic, composites and dendrimers
d) Carbon-based, metallic, composites and dendrimers
(xii) Nano sized polymers built from branched units are called __________
a) Dendrimers b) Composites
c) Carbon-based materials d) Metal-based materials
(xiii) Which property of nanoparticles provides a driving force for diffusion?
a) Optical Properties b) High surface area to volume ratio
c) Sintering d) There is no such property \
(xiv) Which property of Nanomaterials make them suitable to be used for elimination of pollutants?
a) High purity b) Better thermal conductivity
c) Enhanced chemical activity d) Small size
(xv) Nanoscale aluminium oxide increases the _________
a) Conductivity b) Resistance
c) Ductility d) Stability
(xvi) Which of the following should not be a property of implants?
a) Environmental stable b) Biostable
c) Non-toxic d) Nonremovable
(xvii) Which is the disadvantage for implants?
a) More effective b) More prolonged action
c) Significantly small dose d) Need of microsurgery
(xviii) Subcutaneous tissue is an ideal location for implants?
a) True b) False
(xv) Which of the following drugs are used in implants?
a) Pantoprazole b) Mannitol
c) Amlodipine d) Morphine antagonist
(xx) Which of the following is a false statement for vapour pressure pump?
a) The device consists of two chambers
b) A chamber contains the drug solution
c) Drug solution chamber is separated by rigid walls
d) Vapour chamber contains vaporizable fluids
Part-B
Long answer questions. [10x2 = 20 Marks]
Note : Attempt any two questions. Each question carries 10 marks.
Q.1 Give introduction, advantages and disadvantages of implants and osmotic pumps.
Q. 2 Describe the formulation of inhalers.
Q.3 Give the basic concepts of Transdermal drug delivery systems.
Part-B
Short answer questions. [5x7 = 35 Marks]
Note : Attempt any seven questions. Each question carries 5 marks.
Q.1 Give the principles of bio adhesion and formulation considerations of buccal
delivery systems.
Q.2 Write a note on Nasopulmonary drug delivery system.
Q.3 Detail the intra ocular barriers and methods to overcome them.
Q.4 Explain the formulation of transdermal patches of drug delivery system.
Q.5 What are nanoparticles? Write its methods of liposomes. Discuss application.
Q.6 Difference between Liposomes and Niosomes.
Q.7 Detail about Intra uterine devices
Q.8 Write short notes on any three:
a) Ocuserts
b) Monoclonal Antibodies
c) Nebulizers
d) Nanoparticles.
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