Dr.A.P.J.Abdul Kalam University
Bachelor of Pharmacy
Third Semester Main Examination, Dec-2020
Physical Pharmaceutics-I [BP302T]
Time: 3:00 Hrs Max Marks 75
Note : (i) All parts of the question paper are compulsory.
(ii) All question of each part to be attempt at one place.
Part-A
Q.1 Multiple choice questions- [1×20 = 20 Marks]
(i) An Azetropic mixture of two liquids boils at lower temperature than either of them when
(a) It shows negative deviation from Raoult’s law
(b) It shows positive deviation from Raoult’s law
(c) It is Metastable
(d) It is saturated
(ii) The solubility of gases increases in liquid with increasing
(a) Mass (b) Volume
(c) Temperature (d) Pressure
(iii) Normal pH of blood is
(a) 7.4 (b) 7.2 (c) 7.1 (d) 7.0
(iv) Buffer Capacity is the maximum at
(a) pKa = pH (b) pKa< pH
(c) pka = Concentration (d) pka> pH
(v) At Constant temperature the solubility of gas in a liquid is proportional to the
pressure of the gas above it is called as
(a) Roult’s law (b) Graham’s law
(c) Henry’s law (d) Charle’s Law
(vi) The Amorphous form of drug dissolves than the crystalline form
(a) Faster (b) Slower
(c) Equal to one (d) Does not dissolve
(vii) Wetting agents usually have an HLB value in the ranges
(a) 8-16 (b) 9-12
(c) 0-3 (d) 7-9
Page [2]
(viii) The pKw at 25°C is
(a) 14.0 (b) 10 (c) 5.0 (d) 7
(ix) Pair of liquids that are miscible in all proportions are known as
(a) Binary liquids (b) Polar liquids
(c) Concentrated liquids (d) Saturated liquid
(x) Interfaces are important in
(a) Tablets (b) Pastes
(c) Suspensions (d) Emulsion
(xi) Example of chelate
(a) PVP-Iodine (b) Cyclodextrin
(c) Cisplatin (d) Haemoglobin
(xii) EDTA is an example of
(a) Unidentate (b) Bidentate
(c) Oxydentate (d) Multidentate ligand
(xiii) Versatile complexometric agents.
(a) Iodine
(b) Ethylene diamine tetra acetic acid (EDTA)
(c) Sodium hydroxide
(d) Hydrochloric acid
(xiv) Which sentence is false about ligand?
(a) It is act like lewis base
(b) CN¯ is example of unidentate.
(c) It is electron donor group.
(d) EDTA is example of unidentate.
(xv) Surface Tension of Liquid ________________ with increase in temperature
(a) Decrease (b) Increase
(c) No Change (d) None of the Above
(xvi) Which of the following isunidentate ligand.
(a) Ammonia (b) Oxalate ion
(c) EDTA (d) Ethylene diamine
(xvii) The tonicity of Solution can be determined by……………..
(a) Colorimetric method (b) Haemolytic Method
(c) Coligative method (d) Both B & C
Page [3]
(xviii) Velocity of light is maximum in ……………..
(a) Diamond (b) Water
(c) Vaccum (d) Glass
(xix) When solid changes to liquid is called…………….
(a) Melting (b) Condensation
(c) Sublimation (d) Vapourization
(xx) The mass transfer of molecules in a substance from higher concentration to
lower concentration is……………..
(a) Diffusion (b) Osmosis
(c) Active transport (d) Passive transport
Part-B
Short Answer type Question [7x5=35]
Attempt any 7 questions. Each Carry five marks
Q.1 Define Ideal solution and Real solution with the help Raoults Law?
Q.2 Write the methods for determine of surface Tension of Liquid.Explain two
methods?
Q.3 Discuss in detail Properties of various State of Matter?
Q.4 Write Short Note On:
(i) Liquid Crystal
(ii) Eutectic Mixture
(iii) Triple Point
Q.5 What are Surfactants? Give Suitable Chemical Classification of Surfactants
and mention their Important uses?
Q.6 Write Short Note on
(i) Surface Tension
(ii) Interfacial Tension
Q.7 How the Binding of Drugs to Protien can influence their Action.
Q.8 What do you mean by Elevation in Boiling Point?How is Molecular mass of
Solute
Page [4]
Part-C
Long Answer Type Questions [2x10=20]
Attempt any 2 questions. Each carry Ten marks
Q.1 Define Polymorphism and its Classification. What are the different method
used for characterization of polymorphism.
Q.2 Define Complexation. What are the types of complexs? Write detail About
Inclusion Complexes.
Q.3 Explain Various Type of Crystal on the basis force of attraction Giving
SuitableExample.
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